Harrison Hiraki

PhD Candidate
Biomedical Engineering, University of Michigan

hirakih (at) umich (dot) edu

Hometown: Portland, Oregon

Education: BS in Bioengineering, University of Washington, 2018

Research interests: My undergraduate research interest was predominantly in tissue engineering. I worked to engineer a material that best represented the biochemical and biomechanical properties of the kidney cortex microenvironment to help elucidate underlying pathways in kidney disease progression. A growing interest in cancer therapeutic research has led me to the Baker Lab where I am working to understand how matrix mechanical properties affect the mechanism by which cancer cells migrate from the primary tumor, travel through the stroma, and intravasate into nearby microvessels. I aim to develop a representative model of the tumor microenvironment that can be incorporated with patient-derived cancer cells and has translational merit as a high-throughput drug testing device.

Outside of lab interests: Outside of the lab, I enjoy playing basketball and reading about/creating Japanese-style ceramic pottery. I also love exploring new restaurants in A2 and am working to improve my admittedly mediocre cooking skills. Go Huskies and Go Blue!

Publications:

Davidson CD, Jayco DKP, Matera DL, DePalma SJ, Hiraki HL, Wang WY, Baker BM. "Myofibroblast activation in synthetic fibrous matrices composed of dextran vinyl sulfone," Acta Biomaterialia, 2020, doi:10.1013/j.actbio.2020.01.009.

Nagao RJ, Hiraki HL, Phong KT, Xue J, Himmelfarb J, Zheng Y. "Perivascular Cells Direct Endothelial Cell Fate in a Renal Microvascular Disease Model," (In preparation to Kidney Int.). 

Hiraki HL, Nagao RJ, Himmelfarb J, Zheng Y. "Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel," Journal of Visualized Experiments, 2018, doi:10.3791/58314.

Abstracts:

Hiraki HL, Matera DL, Baker BM. "Increasing stromal matrix fiber density promotes multicellular outgrowth from MCF10a spheroids," BMES Annual Meeting, Philadelphia, PA, October 16-19, 2019, podium.

© 2020 Baker Laboratory, Ann Arbor, MI